The unbeaten hosts will face a winless Premier League side on Saturday afternoon, when Arsenal and Southampton clash at the Emirates Stadium.
The Gunners returned to top-flight action following a 2-0 Champions League win over Paris Saint-Germain, while a day earlier Southampton were beaten 3-1 by their southern rivals Bournemouth.
Latest Arsenal vs Southampton team information
Arteta's defensive crisis shows no signs of easing in the near future, with Oleksandr Zinchenko (calf), Kieran Tierney (hamstring) and Takehiro Tomiyasu (knee) all expected to miss the game, while Ben White (groin) and Jurrien Timber (muscle) are new doubts.
Timber only lasted until half-time in the win over PSG, where Mikel Merino made his debut as a substitute following his freak shoulder injury, and the Spaniard will surely boost his hopes of making his first start in place of Thomas Partey this weekend.
The hosts are also without captain Martin Odegaard (ankle), but it is at home that his replacement, Havertz, shines. Havertz could become the first Arsenal player since Pierre-Emerick Aubameyang in 2019 to score in five consecutive Premier League games at the Emirates.
Arsenal were not the only side to suffer a defensive blow on Tuesday, as Southampton defender Jack Stephens was banned for a further two games for using abusive language after being sent off against Manchester United, taking his total suspension to five.
Will Smallbone is likely to return from a thigh injury in time for the trip to north London, but Gavin Bazunu (Achilles tendon) and Kamaldeen Sulemana (ankle) are still not ready to play.
Former Arsenal goalkeeper Aaron Ramsdale is set to become the ninth goalkeeper to face Arsenal in the Premier League after previously representing them. However, only one of the previous eight has kept a clean sheet in his first game against his former club, Emiliano Martinez for Aston Villa in 2020.
Latest Arsenal vs Southampton predicted lineup
Arsenal:
Raya; Calafiori, Saliba, Gabriel, Kiwior; Havertz, Partey, Rice; Saka, Trossard, Martinelli
Southampton:
Ramsdale; Sugawara, Harwood-Bellis, Bednarek, Taylor; Downes, Aribo, Lallana; Fernandes; Dibling, Brereton Diaz
Latest football commentary Arsenal vs Southampton
While PSG have continued to dominate the domestic league in the post-Kylian Mbappe era, the French champions were clearly lacking in attacking creativity at the Emirates Stadium in midweek, where two errors from goalkeeper Gianluigi Donnarumma helped Arsenal.
The Euro 2020 champions failed to clear Leandro Trossard's cross, allowing Kai Havertz to extend his scoring streak at the Emirates. Bukayo Saka then beat his penalty-stopper with a free-kick that flew past everyone and into the net.
Although he usually shows restraint after important victories, Mikel Arteta appeared relaxed and happy after the match as Arsenal secured their third successive home win, and this one was a far easier affair than the six-goal chase against Leicester City last weekend.
The dramatic late win over Leicester moved Arsenal up to third in the table - just a point behind Liverpool and Manchester City - and their unbeaten run in all competitions now stretches to 15 games since being knocked out of the Champions League by Bayern Munich in April.
Thanks to their impressive performance against Leicester, Arsenal are closing in on a Premier League milestone; a win on Saturday would be their 400th home win in the Premier League, a feat only Manchester United (426) have achieved.
As Arsenal approached the historic milestone, Southampton arrived at the Emirates Stadium with a disappointing record of 246 Premier League away defeats - the fifth-highest in the competition's history - and Russell Martin appeared resigned to his fate in his side's latest away defeat.
Against local rivals Bournemouth, Southampton were dominated in the opening 45 minutes as Evanilson, Antoine Semenyo and Dango Ouattara all found the net. Although Taylor Harwood-Bellis pulled one back early in the second half, there was no comeback from Martin.
Southampton are currently above Wolverhampton Wanderers only on goal difference, and while a final decision has not been made on Russell Martin's future, he still has support from a number of quarters.
However, an embarrassing defeat at the Emirates could push the manager closer to the sack. He needs to focus on improving his attacking play ahead of the game; Southampton's chance conversion rate of just 4.4% is the worst in the Premier League in 2024-25.
Southampton fans can take some solace from their three-game unbeaten run against Arsenal, who were forced to draw 3-3 in this fixture two seasons ago. However, Southampton have not beaten Arsenal away from home in a league game since 1987.
Despite having plenty of possession, Southampton have been unable to create a difference, and Arsenal's solid defence will be hard-pressed to be threatened by a Southampton side lacking in strength. Martin's men may be able to hold Arsenal at bay for a short period, but it won't be long before Arteta's side find a way to break down the defence, and the goals could well come in droves.
Arsenal vs Southampton score prediction
Based on the above football comments, we and the world's leading football sites have given the following results for the Arsenal vs Southampton match:
- Sportsmole: Arsenal 4-1 Southampton
- WhoScore: Arsenal 3-0 Southampton
- Our prediction: Arsenal 4-0 Southampton
When and where to watch Arsenal vs Southampton live?
To watch live the match Arsenal vs Southampton in the Premier League taking place at 9:00 p.m. on October 5, viewers can watch on K+ Sport, K+PM or online sports channels. Wish you all have fun watching football.
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