SGGP
Researchers at the Centenary Institute, Australia have just successfully developed a new technology called Invasion-Block used to screen and identify drugs that can be used to prevent the spread of melanoma.
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| Illustration photo by New Atlas |
The team combined Invasion-Block with an automated image analysis workflow adapted from astronomy called Smoothen-Mask and Reveal (S-MARVEL), used to remove artifacts and Significantly improved the quality of datasets on microscopic images of invasive species. They then screened 3.840 drugs in two drug agency-approved compound libraries for their ability to inhibit the formation of invasive tumors in melanoma cells and discovered that, The most effective compounds are kinase inhibitors.
Among the identified kinase inhibitors, the researchers tested the effectiveness of the ataxia-telangiectasia mutation (ATM) inhibitor in the laboratory. They used CRISPR gene editing technology to knock out the gene responsible for ATM kinase expression in melanoma cells and found that the cells became less invasive and did not spread to the lymph nodes. lymph.
