A new breakthrough in the treatment of type 1 diabetes.

Scientists made three modifications before cell transplantation that reduced antigen expression, making it harder for the immune system to recognize and attack foreign cells, and increased the production of the CD47 protein.

Scientists have made a new breakthrough in the treatment of type 1 diabetes.

For the first time in the world , a patient has been able to produce insulin on their own again after receiving a transplant of genetically modified pancreatic islet cells.

According to a study published in the New England Journal of Medicine, a team of American and Swedish scientists used the CRISPR gene-editing tool to make three key changes before cell transplantation.

Of these, two modifications reduce antigen expression, making it harder for the immune system to recognize and attack foreign cells, and the remaining modification aims to enhance the production of the CD47 protein, which acts as a "shield" protecting cells against the innate immune response.

As a result, for the first time, patients no longer need to use immunosuppressant drugs – which have always been a major obstacle in cell or organ transplants.

The patient in the study was a 42-year-old man who had type 1 diabetes since childhood. He received a transplant of pancreatic islet cells taken from a healthy donor, injected into his forearm muscle.

The results showed that after just 12 weeks, the genetically modified cells began producing natural insulin to regulate post-meal blood sugar. This is the first time a type 1 diabetes patient has been able to self-regulate blood sugar without the need for external insulin injections.

Researchers emphasize that this success not only offers hope for millions of people with type 1 diabetes globally, but also opens up prospects for widespread application in cell and organ transplantation to treat many other diseases.

(VNA/Vietnam+)

Source: https://www.vietnamplus.vn/buoc-dot-pha-moi-trong-dieu-tri-benh-tieu-duong-tuyp-1-post1056834.vnp