Excessive fat loss carries risks comparable to obesity.

New research shows that excessive fat loss is not as safe as many people think. When fat tissue is depleted, the risk of metabolic disorders, diabetes, and fatty liver disease may increase.

New research suggests that excessive fat loss or abnormal fat reduction can also disrupt metabolism, increasing the risk of diabetes and other health problems. (Source: Shutterstock)

In popular belief, body fat is often seen as "excess" that needs to be eliminated. However, new research published in The Journal of Clinical Investigation (USA) shows that adipose tissue is not simply a place to store energy, but is also an active "organ" that plays a vital role in metabolic health.

Obesity has long been known to increase the risk of diabetes, cardiovascular disease, and many other metabolic disorders. However, according to scientists , fat loss or abnormal fat distribution can also have equally serious consequences. A prime example is FPLD2, a rare disorder that causes the body to lose fat and distribute it abnormally, leading to an increased risk of diabetes and other metabolic disorders.

Based on this reality, Dr. Elif Oral, clinician and professor of Metabolism, Endocrinology and Diabetes, Dr. Ormond MacDougald, research fellow Jessica Maung, and their colleagues from the University of Michigan Medical School (USA) focused on clarifying the changes that occur within adipose tissue when this tissue is weakened in lipodystrophy.

The research team found that the fat cells had undergone very serious changes. To verify this, they tested on mice and discovered that the lamin A/C gene was selectively switched off in the fat cells. This is also the gene that is mutated in people with FPLD2.

Analysis of both mouse and human tissue revealed serious disruptions in gene activity. These changes rendered fat cells unable to efficiently store and process lipids. Simultaneously, both fat cells and neighboring immune cells entered an inflammatory state. Furthermore, the mitochondria within fat cells lost their normal function.

According to scientists, it is this combination of factors that creates an environment where fat tissue weakens and gradually disappears. When fat tissue no longer functions normally, the body also loses a crucial link in regulating fat and releasing essential metabolic hormones, increasing the risk of diabetes and fatty liver disease.

Dr. Elif Oral noted that this finding highlights the crucial role of healthy adipose tissue in maintaining metabolic stability and ensuring efficient bodily functions. According to her, type 2 diabetes is not only a disease of beta cells but also of fat cells.

Based on the research results, scientists believe that future treatment approaches may not only focus on controlling fat levels, but also on protecting or restoring the function of adipose tissue.

Source: https://baoquocte.vn/giam-mo-qua-muc-rui-ro-khong-kem-beo-phi-382065.html