According to Neuroscience News, new research published in the journal BMC Medicine shows that antidepressants can accelerate cognitive decline in people with dementia.
Antidepressants may accelerate cognitive decline in people with dementia - Photo: FREEPIK
Antidepressants are commonly used to relieve symptoms such as anxiety, depression, aggression, and sleep disturbances in patients with dementia.
However, a new observational study based on data from Sweden shows that dementia patients treated with antidepressants had higher levels of cognitive decline than patients not taking the drugs.
The study was based on an analysis of data from 18,740 patients, of whom approximately 23% were treated with antidepressants. During the study period, a total of 11,912 antidepressant prescriptions were recorded, with selective serotonin reuptake inhibitors (SSRIs) accounting for 65%.
"Depressive symptoms can both worsen cognitive impairment and affect quality of life, so treating them is important.
The study results help doctors and healthcare professionals choose more suitable antidepressants for patients with dementia," said Dr. Sara Garcia Ptacek, a researcher at the department of neurology, care science and society at Karolinska Institutet and lead author of the study.
Researchers from Karolinska Institutet and Sahlgrenska University Hospital (Gothenburg) tracked patients' cognitive progress over time, comparing groups that took and did not take antidepressants, as well as between different types of medication.
The study also found differences between different drugs. The SSRI escitalopram was associated with the fastest rate of cognitive decline, followed by citalopram and sertraline. Mirtazapine, a drug with a different mechanism of action, had less negative cognitive effects than escitalopram.
Source: https://tuoitre.vn/thuoc-chong-tram-cam-day-nhanh-suy-giam-nhan-thuc-20250310082537796.htm
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