China: Mechanism of cancer progression from intestinal bacteria due to obesity

A team of Chinese cancer researchers has discovered a new mechanism by which gut bacteria associated with obesity may promote the development of cancer in patients.

A woman suffering from obesity.

High-fat diets (HFDs) are considered a risk factor for the development of several cancers, largely due to the disruptive effects of fat on the gut microbiota. However, the exact role of HFDs in cancer progression has not been well understood.

In a study conducted by scientists at Sun Yat-sen University, the team established several models of cancer in mice and found that the fat-fed microbiota released abundant amounts of leucine, an amino acid found in many proteins.

According to the above study, elevated leucine concentrations in peripheral blood were found to be associated with poor clinical outcomes in female patients with breast cancer.

In addition, abnormal gut microbiota have been implicated in the development of resistance to chemotherapy and some immunotherapies for breast cancer, lung cancer, and melanoma.

The researchers say the findings offer new hope for cancer-preventing treatments that target abnormal gut microbiota metabolism.

nhandan.vn

Source: https://baolaocai.vn/trung-quoc-co-che-benh-ung-thu-tien-trien-tu-vi-khuan-duong-ruot-do-beo-phi-post383801.html