On July 21, Hue Central Hospital held a discharge ceremony for four special pediatric patients, marking an important step forward in the treatment of hematological diseases in children. Notably, two cases of allogeneic stem cell transplantation with incompatible blood types were successfully performed for the first time in Vietnam using the immune fusion technique.
The two transplants, including NHH (2 years old, Bac Giang ) and LNH (10 years old, Da Nang), were performed by infusing the donor's blood group into the recipient's body by drip, increasing day by day to reduce the antibody titer. When the titer drops below 1/32, red blood cell separation is no longer necessary.
This technique helps preserve the number of stem cells and increase the recovery rate after transplantation. Both children recovered stable platelets and white blood cells.
From September 2024 to present, Hue Central Hospital has successfully performed 10 allogeneic bone marrow transplants to treat Thalassemia, along with 50 autologous stem cell transplants to treat solid tumors. These successes have helped many children end their dependence on blood transfusions, prolong their lives, and significantly improve their quality of life.
Worldwide , ABO-incompatible stem cell transplantation (HSCT) has been recorded since the 1970s, with the first 81 successful cases.
By 2008, the use of post-transplant immunosuppressive drugs (cyclophosphamide) had significantly expanded the ability to transplant between blood-type or HLA-mismatched donors and recipients, contributing to reduced complications and increased treatment efficacy.
Vietnam's successful application of immune fusion technology in blood group incompatibility transplantation for the first time in July 2025 is a pioneering step, affirming the capacity for high-tech integration in medicine.
This achievement not only creates a breakthrough in the treatment of congenital hemolytic anemia, but also opens up prospects for effective treatment of other complex hematological diseases such as bone marrow failure, congenital immunodeficiency, and recurrent cancer.
Source: https://nhandan.vn/ap-dung-thanh-cong-ky-thuat-dung-hoa-mien-dich-trong-ghep-bat-dong-nhom-mau-tai-viet-nam-post895220.html
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