World's first clinical trial on brain tumor treatment

Australian scientists have announced a major advance in the treatment of brain tumours by using the Brain Perioperative Testing Platform (BrainPOP) for the first time to directly observe the effects of a new drug during surgery.

New treatment for brain tumors. (Source: wehi.edu.au)

The type of cancer studied was low-grade glioma (LGG), a slow-growing disease that severely affects the quality of life of patients, mainly young people in their prime.

LGG is associated with a particular gene mutation called IDH, which makes the disease difficult to treat and has long been considered "untreatable".

However, researchers have found a solution to a new treatment, thanks to the discovery of mutations in LGG and an innovative treatment process.

In the experimental study, scientists used Safusidenib - an oral drug that can inhibit the mutated IDH1 gene .

By observing tumour samples before and after taking the drug, the research team from the Royal Melbourne Hospital (RMH) and the Peter MacCallum Cancer Centre directly witnessed positive changes in cancer cells.

This promising result was recently published in the journal Nature Medicine .

"This is not only a turning point in how we test the effectiveness of treatments, but it also opens up new opportunities for a group of patients who have been disadvantaged by a serious illness," said Kate Drummond, director of neurosurgery at RMH and lead investigator of the project.

Meanwhile, Dr Jim Whittle, who works at the Peter MacCallum Cancer Centre - the leader of the research team - said that tests such as taking biopsy samples before and after treatment to measure the impact are common in many other types of cancer, but because of the complexity of neurosurgery, they have never been applied to brain tumors.

Research demonstrates that BrainPOP is a safe, effective platform that reveals detailed drug effects in the brain, enabling patients and families to make personalized treatment decisions.

Source: https://baoquocte.vn/thu-nghiem-lam-sang-lan-dau-tien-tren-the-gioi-ve-phuong-phap-dieu-tri-u-nao-325661.html