7 Supplements to Avoid If You're Taking Weight Loss Pills

Here are 7 supplements to keep in mind when taking with weight loss drugs:

1. St. John's Wort supplements reduce the effectiveness of weight loss drugs

Available as a tea, supplement, and liquid tincture, St. John's Wort is commonly used to treat mild cases of depression. However, this supplement can cause side effects including dizziness, fatigue, sensitivity to light, and interactions with many other medications.

For weight loss medications. St. John's Wort supplements decrease drug levels, thereby reducing the effectiveness of many weight loss medications.

2. Green tea extract

Green tea is rich in polyphenols, which can lower blood pressure, improve cardiovascular health, and aid in weight loss. In fact, some people combine this supplement with diet pills to maximize its effects.

However, caution should be exercised when using green tea extract with certain weight loss medications. With its high caffeine content, green tea extract can interact with stimulant weight loss medications, causing side effects such as restlessness, sleep disorders, and increased blood pressure…

This interaction also occurs with any supplement that contains caffeine. While caffeine is often used to boost metabolism, high doses can cause or worsen anxiety, high blood pressure, and insomnia, especially when taken with stimulant-based weight loss medications. It can exacerbate these side effects, leading to potential health risks.

Green tea supplements should not be combined with weight loss drugs.

3. Vitamin C

Vitamin C is one of the most popular supplements on the market, often used to boost immune function, improve the health of bones, teeth, ligaments, blood vessels…

However, it's best to avoid vitamin C when taking certain weight loss peptides. Vitamin C can worsen reflux, which is a common side effect of this weight loss drug.

Vitamin C may worsen side effects of weight loss drugs.

4. Bitter orange

Bitter orange supplements are commonly used in OTC weight loss products. When combined with prescription weight loss drugs, especially those containing stimulants, it can significantly increase the risk of cardiovascular side effects such as increased blood pressure and heart palpitations.

5. Turmeric

In addition to its anti-inflammatory effects due to its antioxidant properties, some people also use turmeric supplements to aid in weight loss and digestion. However, curcumin or turmeric supplements should not be combined with weight loss drugs.

Like vitamin C, turmeric can worsen reflux. Turmeric can inhibit the enzyme DPP4, which increases the breakdown of GLP-1. This could theoretically make the weight loss drug more potent or longer lasting, causing more side effects.

Turmeric should also not be used with weight loss drugs.

6. Activated charcoal and clay supplements

Activated charcoal and clay supplements are said to reduce gas, bloating, and help regulate digestion. Some people also take these supplements to bind and remove toxins from the body, although there is little research to support this claim.

However, if you are taking weight loss pills, you should avoid this combination. Charcoal, clay, or other detoxifying binders… tend to cause constipation, which will aggravate the constipation side effects of weight loss pills.

Charcoal and clay tend to aggravate the constipation side effects of diet pills.

7. Butyrate

Butyrate is a short-chain amino fatty acid that is naturally produced by the body when it breaks down fiber in the digestive system. While the best way to increase your natural butyrate levels is to eat fresh fruits and vegetables that contain soluble, fermentable fiber, some people turn to supplements.

However, butyrate may interact with weight loss drugs like ozempic or wegovy, which are a class of drugs called GLP-1 agonists.

Butyrate in the form of sodium butyrate, tributyrin, or ketone esters also increases GLP-1. While these are helpful in helping patients wean themselves off weight loss medications once they reach their weight loss goals, they sometimes exacerbate side effects of weight loss medications while they are being used.

DS. Kim Thuy

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