A group of scientists in Boston (USA) has just made an important step forward in the study of human longevity when successfully establishing a stem cell bank from the blood of people over 100 years old.
Centenarians have an extraordinary ability to recover from injury and illness. (Source: AFP) |
On November 29, Nature Magazine quoted Mr. George Murphy, a stem cell biologist at the Chobanian & Avedisian School of Medicine at Boston University, as saying: "Centennials have an extraordinary ability to recover from injury and disease."
Scientists believe that the secret to longevity may lie in a unique genetic makeup that helps older people avoid many diseases. However, research is difficult because the number of people who live to be over 100 years old is very rare, making collecting blood and tissue samples time-consuming and laborious.
To overcome this limitation, the team collaborated with expert Tom Perls, head of the New England Aging Study — the largest study of people over 100. They searched for study subjects through voter rolls, newspaper articles, and long-term care facilities.
Remarkably, many study participants maintained good cognitive abilities and self-care.
Scientists have succeeded in extracting blood cells from about 30 elderly people and converting them into pluripotent stem cells, which are capable of developing into any type of cell in the body.
Early experiments have shown that neurons created from stem cells of centenarians have a unique protein quality control mechanism. When exposed to stressors, these cells are able to react quickly and efficiently, separating harmful proteins from beneficial proteins at a higher rate than normal.
In the future, scientists hope to be able to develop many other types of cells such as liver, muscle, intestine, and even "mini" organs from this stem cell source, opening up many new research directions on aging and human longevity.
Source
Comment (0)