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Top 10 anti-aging creams for 40-year-olds that help skin 'turn back time' without a spa

Despite the age of 40, you still have youthful, bright skin like a girl in her twenties with anti-aging cream without having to go to the spa. So let's find out the top 10 anti-aging creams for 40-year-olds to 'turn back time' that are being sought after by many beautiful women today.

Báo Thanh niênBáo Thanh niên20/04/2025

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 1.

1. Image The Max Stem Cell Crème anti-aging skin rejuvenation cream

Top anti-aging creams for 40-year-olds come from the famous American brand Image Skincare. Image The Max Stem Cell Creme is a high-tech cream designed to comprehensively solve skin aging problems, especially suitable for skin after 30 years old. The product applies Vectorize Technology™ - modern transmission technology to help nutrients penetrate deeply and promote long-lasting effects. The formula contains "golden" active ingredients such as Peptide, Argireline, Tetrahexyldecyl Ascorbate (stable vitamin C), Photosomes and apple stem cell extract; all together activate the mechanism of powerful skin recovery and regeneration.

Thanks to its ability to deeply moisturize and stimulate the production of new cells, the product not only reduces wrinkles and improves elasticity, but also helps fill in wrinkles and crow's feet, while minimizing sagging skin. The skin's natural protective layer is also enhanced through the restoration of epidermal lipids, helping to fight against harmful environmental factors.

This is an ideal choice for dehydrated, dull, prematurely aging skin, skin affected by UV rays, stress, or after treatments such as laser, chemical peel. The cream texture is smooth, absorbs quickly, does not clog pores, brings a comfortable feeling and obvious effects after a short time of use.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 2.

Main ingredients: Apple stem cell extract, edelweiss flower, Peptide, Argireline, Tetrahexyldecyl Ascorbate, Photosomes and Roxisomes.

Outstanding advantages:

  • Promotes cell regeneration, repairs damage and protects skin from oxidation, effectively reducing wrinkles.
  • Advanced Vectorize Technology™ optimizes nutrient absorption, instantly brightening and smoothing skin.
  • Stimulates collagen and elastin production, increases firmness, reduces sagging and wrinkles around eyes and mouth.
  • Deeply moisturizes, strengthens the natural protective layer, helps skin stay plump, radiant and healthy every day.
  • Soothes irritation, anti-inflammatory, improves dry, red or sensitive skin, brings a comfortable feeling.
  • Fills in fine lines and wrinkles, creating a smooth, vibrant skin surface.
  • The cream texture is light, smooth, absorbs quickly, is not greasy, suitable for all skin types without causing stuffiness.
  • Alcohol-free, mild fragrance, relaxing, safe for sensitive skin or post-treatment skin.

Disadvantages: The price is a bit high but the anti-aging effect is outstanding so women are still willing to invest to have youthful skin regardless of age.

Official listed price: 3,724,000 VND/ 48g

Overall rating: 9.5/10

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 3.

Genuine product commitment with attractive promotions and valuable gifts here: https://maihan.vn/image-skincare/kem-tre-hoa-da-image-the-max-stem-cell-creme.html

2. Rejuvaskin Facial Moisturizer Anti-Aging Cream

On the top of the list of anti-aging creams for 40 years old is the name from the famous pharmaceutical cosmetic brand Rejuvaskin for more than 35 years in the US. Rejuvaskin Facial Moisturizer has an advanced formula with Revita-D™ complex, providing outstanding dual effects. It both supports the activation of vitamin D synthesis in the skin and strengthens the natural protective barrier to keep the skin healthy against environmental impacts.

Not only does it deeply nourish, Rejuvaskin Facial Moisturizer is also particularly effective in reducing wrinkles, reducing crow's feet, softening dry, rough skin and improving uneven skin tone. Thanks to its elasticity-enhancing mechanism, the cream also helps prevent sagging and loose skin, keeping the skin's surface smooth and firm.

Suitable for all skin types, including sensitive or easily irritated skin, Rejuvaskin Facial Moisturizer feels gentle, does not clog pores, and helps improve skin from deep within. After 4 weeks of use, you will feel your skin become fresh, even-toned, plump and full of vitality as if it has been reborn.


Main ingredients: Revita-D, Acquacell, coffee extract, sunflower oil, avocado extract.

Outstanding advantages:

  • Stimulates vitamin D synthesis in the skin, providing deep moisture and anti-aging effects from within.
  • Provides intensive moisture and locks in moisture; while regenerating the natural protective layer, helping skin stay healthy against UV rays and environmental factors.
  • Enhances antioxidants, deeply moisturizes, nourishes skin cells, effectively reduces wrinkles and crow's feet.
  • Promotes collagen and elastin production, prevents skin structure breakdown, keeps skin tight and youthful, reduces sagging and wrinkles.
  • The creamy texture is smooth, absorbs quickly, creating an ideal moisturizing layer as a base before makeup.
  • Gentle, relaxing fragrance, providing a comfortable experience every time you use it.
  • The ingredients do not contain preservatives or synthetic fragrances, are benign and safe for all skin types, including sensitive skin.

Disadvantages: Being distributed by many different individuals and distributors without control over product quality.

Official listed price: 1,420,000 VND/ 50ml

Overall rating: 9.5/10

Genuine product commitment with up to 24% discount and valuable gifts here: https://scarheal.com.vn/scar-heal/kem-phuc-hoi-nuoi-duong-ngua-lao-hoa-da-rejuvaskin-facial-moisturizer.html

3. Obagi Clinical Retinol 0.5 Retexturizing Cream Anti-Aging Moisturizer

Top 3 anti-aging creams for 30-40 year olds include products from the American pharmaceutical cosmetic brand Obagi. Obagi Clinical Retinol 0.5 Retexturizing Cream is a comprehensive skin care solution with a formula combining pure Retinol, vitamin C and natural plant extracts that both moisturizes, is a powerful antioxidant and helps improve skin surface structure.

Thanks to its cell regeneration mechanism, the cream helps to reduce wrinkles, reduce dark spots, even out skin tone and bring a radiant, smoother appearance day by day. Vitamin C contributes to increasing brightness, while Retinol helps to reduce blemishes and rebuild the skin from within, helping the skin become fresh, firm and naturally shiny.

Obagi Clinical Retinol 0.5 Retexturizing Cream also acts as a "shield" to protect the skin from harmful environmental factors such as pollution, sunlight or free radicals. For those who are looking for a solution to improve premature aging, Obagi Retinol 0.5 is an indispensable companion in the skincare routine to restore and rejuvenate the skin.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 4.

Main ingredients: Retinol, Vitamin C, Vitamin E, green tea extract, chamomile extract, rum essential oil.

Outstanding advantages:

  • Instantly moisturizes, leaving skin smooth and soft from the first use.
  • Stimulates superior cell regeneration, fills in wrinkles, helps skin become plump, firm and youthful.
  • Reduces dark spots, freckles, improves even skin tone, brings radiant skin.
  • Restructures damaged skin, increases elasticity, prevents sagging and signs of aging.
  • Promotes blood circulation effectively, nourishes the skin to be rosy, bright and full of vitality.
  • Helps prevent acne, anti-inflammatory and antibacterial, keeps skin clean, healthy and smooth.
  • The cream has a light texture, absorbs quickly, does not clog pores or feel heavy.
  • Integrating 0.5% Retinol with advanced technology, gentle, non-redness, non-stinging, non-irritating. Ideal for beginners and sensitive skin.

Disadvantages: Poor quality goods have appeared at prices much lower than listed prices.

Official listed price: 1,520,000 VND/ 28g

Overall rating: 9/10

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 5.

  Genuine product commitment and up to 19% discount here: https://maihan.vn/obagi/kem-duong-chong-lao-hoa-obagi-clinical-retinol-0-5-retexturizing-cream.html

4. VI Derm Retinol Age-Defying Treatment Moisturizer

In the top 4 anti-aging creams for 40-year-olds is a product from the high-end pharmaceutical cosmetic brand VI Derm, also from the United States. VI Derm Retinol Age-Defying Treatment Moisturizer is considered the "key to skin rejuvenation" thanks to its improved formula with a trio of outstanding active ingredients including Retinol, Azelaic Acid and 10% Glycolic Acid. This combination not only helps to enhance the ability to fight harmful free radicals, but also helps to improve skin tone, reduce dark spots, improve elasticity and promote collagen production, a key factor in keeping skin firm and youthful.

The unique highlight of the product lies in the technology of transmitting Retinol combined with vitamin C in the form of THD Ascorbate, an oil-soluble form of vitamin C, which has the ability to penetrate many times deeper than conventional derivatives. Thanks to that, the active ingredients can effectively affect deeper layers of the skin, bringing about obvious anti-aging effects without causing peeling or irritation even on sensitive skin.

With a light, easily absorbed texture and a gentle yet powerful formula, the product helps the skin become bright, smooth and vibrant after a short time of use. This is the ideal choice for those who are looking for an intensive skin care solution to restore, regenerate and maintain lasting beauty over time.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 6.

Main ingredients : Retinol, Vitamin C (THD Ascorbate), Aloe Vera, Glycolic Acid 10%, Azelaic Acid.

Outstanding advantages:

  • Deeply moisturizes, giving you smooth, vibrant skin from the first use.
  • After 7 days, skin is bright, smooth, firm, radiant with clear new vitality.
  • Reduces wrinkles, improves elasticity, helps skin plump and youthful in weeks.
  • Reduces dark spots, brown spots and acne scars effectively after 4-6 weeks of continuous use.
  • Stimulates collagen production, regenerates skin, giving a youthful, radiant appearance.
  • Brightens and evens skin tone quickly, giving skin a naturally rosy white color and radiance.
  • Nourishes the dermis, regenerates cells, helps skin healthy and full of energy.
  • Luxurious turquoise bottle packaging, convenient pump design, optimal nutrient protection.
  • Light cream texture, fast absorption, non-greasy, ideal as a moisturizer before makeup.
  • Safe ingredients, integrated with Retinol and Vitamin C technology (THD Ascorbate), reduce irritation, do not cause peeling, safe for all skin types.

Disadvantages: High price but quite large capacity and above all, the effect of filling wrinkles and rejuvenating the skin is outstanding, so it is still the top choice of skincare enthusiasts.

Official listed price: 3,500,000 VND/ 50ml

Overall rating: 9.5/10

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 7.

  Genuine product commitment with up to 19% discount here: https://maihan.vn/vi-derm/kem-duong-chong-lao-hoa-vi-derm-retinol-age-defying-treatment-moisturizer.html

5. PageOne Matrix Repair Pro + Exosome Anti-Aging Serum

Top 5 anti-aging products for 40-year-olds cannot forget the PageOne brand from Korea. Page One Matrix Repair Pro + Exosome Serum is a breakthrough anti-aging essence, applying new generation Exosome technology combined with biological growth factors and regenerative proteins, providing a comprehensive skin care solution from deep within. Thanks to the ability to activate natural collagen production and promote cell renewal, the product helps improve elasticity, firm the skin, and slow down signs of aging such as sagging or fine lines.

After 6-12 weeks of regular use twice a day, users can clearly feel the change: the skin gradually becomes smoother, more radiant and younger every day. Not only limited to anti-aging effects, the serum also acts as a "revival medicine" for weak skin. Thanks to its ability to rebuild the natural protective barrier, deeply moisturize and soothe damage, PageOne Matrix Repair Pro + Exosome serum is especially effective for skin that has been infected with corticosteroids, or after laser treatments or chemical peels.

With its outstanding functions, this is a "powerful assistant" in the skin care routine of women aged 30 and over, especially when the skin begins to enter a stage of natural decline in vitality and firmness.


Main ingredients: Multipeptides, epidermal growth factor EGF, Bakuchiol 0.5%, Hyaluronic Acid, Liposome - Ginseng Exosome, Biotin, Vitamin C, Riboflavin.

Outstanding advantages:

  • Provides deep moisture, nourishes smooth skin, slows down the aging process from within.
  • Promotes collagen and elastin production, protects skin structure, giving you youthful, radiant skin.
  • Reduces wrinkles, crow's feet, smooths and visibly firms skin.
  • Naturally brightens, improves evenness, and gives a fresh complexion after 6-12 weeks of regular use morning and night.
  • Strengthens the protective layer, protects against harmful UV rays and the environment, and prevents premature aging.
  • Helps restore sensitive skin, damaged by corticosteroids, helps skin healthy and full of vitality.
  • The serum texture is super light, absorbs quickly, does not cause skin irritation or clog pores.
  • Natural, vegan, gentle ingredients, minimize irritation, suitable for all skin types, even thin, weak skin.

Disadvantages: Warning: Each drop of PageOne essence contains a lot of nutrients. Do not apply too much because the skin will not absorb it all and it will be a waste.

Official listed price: 1,500,000 VND/ 30ml

Overall rating: 9.5/10


Genuine product commitment with attractive promotions up to 19% here: https://pageone.com.vn/san-pham/serum-chong-lao-hoa-page-one-matrix-repair-pro-exosome.html

6. SVR Hydracid C20 Creme Anti-Wrinkle Cream

Top 6 anti-aging creams for 40-year-olds include the super product from the famous French brand SVR. SVR Hydracid C20 Crème is an advanced skin care solution, featuring 20% ​​pure vitamin C, combined with many powerful antioxidants, helping to protect the skin from free radicals, the main cause of premature aging.

With the ability to deeply moisturize and promote cell regeneration, the product helps to fade dark spots, wrinkles and dull skin areas, thereby helping the skin become brighter, smoother and more radiant every day. Not only does it significantly improve the aesthetics, the cream also contributes to improving the elasticity and resistance of the skin.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 8.

Main ingredients: 20% vitamin C, Hyaluronic Acid, Glycerin, Shea Butter.

Outstanding advantages:

  • Deeply moisturizes, keeps skin smooth, effectively slows down signs of aging.
  • Skin is plump, wrinkles are improved, dark spots and brown spots fade quickly.
  • After 7 days, skin is bright, smooth, radiant with clear changes.
  • Improves uneven skin tone, revealing bright, even skin in weeks.
  • Nourishes healthy skin, protects against free radical damage.
  • Light orange cream texture, absorbed immediately upon application to the skin.
  • Concentrated yet gentle vitamin C formula, does not cause irritation or stinging, redness or burning sensation. Suitable for all skin types, including sensitive skin.

Disadvantages: The market is in chaos and product quality is not controlled.

Official listed price: 1,200,000 VND/ 30ml

Overall rating: 9/10

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 9.

Genuine product commitment with attractive offers here: https://maihan.vn/svr/kem-chong-nhan-svr-hydracid-c20-creme.html

7. White Doctors Skin Lightening Anti-Aging Facial Cream

Top 7 anti-aging creams for 40-year-olds that are "crazy" about beautiful women come from the White Doctors brand of EBC Vietnam. White Doctors Skin Lightening is an integrated anti-aging cream line, featuring a formula containing hydrolyzed collagen, omega-3 and essential vitamins, helping to nourish the skin from deep within, restoring its smoothness and youthfulness over time.

Not just a whitening product, the formula is also enhanced with anti-aging properties, helping to fade dark spots, improve wrinkles and prevent early signs of aging. With 2-in-1 effectiveness, White Doctors Skin Lightening is loved by many people for its ability to brighten the skin while protecting and restoring damaged skin.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 10.

Main ingredients: Artemia Extract from France, Brewer's Yeast from France, Centella Asiatica Extract - Gotu Kola from Italy.

Outstanding advantages:

  • Optimum moisture, giving smooth, vibrant and radiant skin.
  • Reduces wrinkles, increases firmness and elasticity, helps skin look younger after use.
  • Brightens skin tone clearly after 4 weeks, effectively reduces dark spots and freckles.
  • Outstanding skin tone balance, giving you naturally rosy white skin, fresh and full of energy.
  • The cream texture is light and thick, absorbs quickly, leaving no greasy or sticky feeling on the skin.
  • Safe, benign formula, suitable for all skin types, including sensitive skin.

Disadvantage: The product has a thick cream texture, so when spreading it, you need to spread it carefully and only a thin layer is enough.

Official listed price: 780,000 VND/ 40g

Overall rating: 9/10

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 11.

  Genuine product commitment with up to 29% discount here: https://maihan.vn/white-doctor/Kem-trang-da-mat-chong-lao-hoa-White-Doctors.html

8. SK-II RNA Power Radical New Age Anti-Aging Cream for 40s

Top 8 is anti-aging cream for 40 years old from Japanese brand SK-II. SK-II RNA Power Radical New Age anti-aging cream with yeast protein extract, Chlolleragan helps increase elasticity and effectively improve wrinkles for youthful skin.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 12.

Main ingredients : Hydrolysis technology from Soybeans and protein in yeast, Chlolleragan.

Outstanding advantages:

  • Instantly hydrates for plump, smooth skin.
  • Prevents signs of aging such as wrinkles and sagging.
  • Promotes collagen and elastin production to fill in wrinkles and crow's feet.

Disadvantages: The price is a bit high and deep wrinkles require persistent use for a long time to see results.

Official listed price: 3,800,000 VND/ 80g

Rating: 8/10

9. Paula's Choice Resist Intensive Repair Cream

Top 9 is an anti-aging product from the leading brand Paula's Choice in the US. Paula's Choice Resist Intensive Repair Cream with 0.01% Retinol combines powerful natural antioxidants to deeply hydrate and quickly lock in moisture, maintaining smooth, hydrated skin for 24 hours. The product also promotes cell regeneration from within, improving signs of aging for smooth, youthful skin.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 13.

Main ingredients: Peptide, Retinol, Ceramide, Niacinamide, Antioxidants.

Outstanding advantages:

  • Moisturizes quickly, leaving skin smooth and soft from the first use.
  • Skin is visibly firmer and radiant after just a few applications.
  • Reduces wrinkles, increases firmness after 1-2 months of continuous use.
  • Brightens and evens skin tone effectively in 4-6 weeks, giving you a fresh skin.
  • Promotes collagen production, helps skin stay youthful and vibrant.

Disadvantage: There are too many distributors with large price differences without quality control on each product.

Official listed price: 1,055,000 VND/ 50ml

Overall rating: 8.5/10

10. OHui Age Recovery Cream anti-aging skin cream

Top 10 anti-aging skin creams for 40 years old from Korean brand OHui. With Baby Collagen™, OHui Age Recovery Cream enhances collagen and elastin production and prevents breakage, maintaining youthful, fresh and vibrant skin regardless of age.

Top 10 kem chống lão hóa tuổi 40 giúp da ‘quay ngược thời gian’ không cần spa- Ảnh 14.

Main ingredients: Baby Collagen™, Baby Collagen Keeper™, Titanium Dioxide.

Outstanding advantages:

  • Deeply moisturizes, keeps skin plump, prevents early signs of aging.
  • Improves skin texture, reduces deep wrinkles, and gives a firm, healthy glow.
  • Reduces wrinkles in the eyebrow area, between the eyebrows, corners of the mouth and smile lines, giving a youthful, radiant look

Disadvantage: Has a fragrance so many women do not like this.

Official listed price: 2,400,000 VND/ 50ml

Overall rating : 8/10

So the beautiful ladies have found a solution to maintain smooth, hydrated, youthful and bright pink skin for a long time, right? But the beautiful ladies need to be alert and be smart consumers. No matter which brand of anti-aging cream for 40 years old you choose, you should buy it from the leading reputable and genuine distributors in Vietnam today such as Mai Han Cosmetics.

Source: https://thanhnien.vn/top-10-kem-chong-lao-hoa-tuoi-40-giup-da-quay-nguoc-thoi-gian-khong-can-spa-185250420172730568.htm


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