Dr. Ahmed El-Sohemy, a professor of nutritional science at the University of Toronto (Canada), said: Sensitivity to caffeine largely depends on the CYP1A2 gene. This gene controls an enzyme called CYP1A2, which functions to break down and eliminate caffeine from the body, and the rate of caffeine metabolism depends on the variant of this gene in each individual.
Individuals with two copies of the CYP1A2 variant will have a rapid ability to metabolize caffeine. Those with one copy – who metabolize slowly – will be more sensitive to caffeine. The rest, lacking copies of the CYP1A2 gene, are quite sensitive to caffeine.
Ideally, you should only drink 2-3 cups of unsweetened black coffee per day.
How does genetics influence coffee drinking preferences?
Genetics also influences coffee preferences. A 2021 study, published in the scientific journal Scientific Reports, found that people with a genetic predisposition to caffeine sensitivity are less likely to enjoy the bitterness of black coffee, and therefore prefer coffee with milk.
Conversely, a 2021 study by the Northwestern University Feinberg School of Medicine (USA) found that people with a genetic predisposition to metabolize caffeine faster prefer dark, bitter coffee, according to the medical journal Neuroscience .
The study's lead author, Dr. Marilyn Cornelis, associate professor of preventive medicine nutrition at Northwestern, said: "People who drink black coffee, especially unsweetened black coffee, also enjoy other bitter foods like dark chocolate. These people metabolize caffeine faster, and therefore they drink more coffee."
However, expert Cornelis says that ideally, you should only drink 2-3 cups of unsweetened black coffee per day.
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